With a cure for the Red Virus and the goal to save the human race, Navy Captain Tom Chandler and his crew return to the States unsure of what they will find. As the crew seeks to find survivors and their families, they encounter a new, emerging enemy whós vying for control and may hinder the mass production of the cure.

Following the epic second-season cliffhanger, the highly anticipated third season finds the crew of the USS Nathan James shifting their attention to Asia after President Michener hears rumblings that the Chinese leader, President Peng, has been hoarding the "Scott cure" instead of distributing it to the people in the region.