After sixteen-year-old Raina learns that she is a perfect match for donating bone marrow to a leukemia patient in Virginia, she discovers that the young woman is the sister she never knew she had.
Fourteen-year-old Darcy's life undergoes a drastic change when her mother is diagnosed with breast cancer in 1974 and is unable to help Darcy deal with the teenage struggles of starting high school, falling in love, and worrying about the Vietnam War.
With the support of her two best friends, sixteen-year-old Kathleen tries to balance her summer volunteer work at the hospital with her responsibilities caring for her mother, who has multiple sclerosis, and her attraction to a handsome boy.