Fifteen-year-old Regan's life, which has always revolved around keeping her older brother Liam's transsexuality a secret, changes when Liam decides to start the process of "transitioning" by first telling his family and friends that he is a girl who was born in a boy's body.
Fourteen-year-old Nick has a three-legged dog named Lucky 2, some pet fish, and two mothers, whose relationship complicates his entire life as they face prejudice, work problems, alcoholism, cancer, and finally separation.